2 This vitamin K deficiency would limit the post-translational activation by carboxylation and phosphorylation of multiple proteins related to the inhibition of vascular calcification ( K-alcification) (osteocalcin, Bone-Gla protein, Matrix-Gla protein, among other vitamin K-dependent proteins), in addition to their effects on the classic coagulation pathways ( K-oagulation). In recent years, the distinction between vitamin K 1 (phylloquinone or phytomenadione) and vitamins K 2 (menaquinones) has been emphasised and, in the nephrology community, these vitamins have gained importance as it has been recognised that vitamin K deficiency is very common in kidney patients, in particular those on renal replacement therapy. These data from the summary of product characteristics were obtained from experimental pre-clinical studies in rats and dogs and in vitro studies. 1 In this article, we underlined that sevelamer can reduce the absorption of fat-soluble vitamins D, E and K and folic acid (according to the summary of product characteristics), although with debatable clinical impact.
We recently published an editorial in the journal Nefrología to draw attention to a little known aspect of phosphate binders, specifically their potential pharmacological interactions.
0 kommentar(er)
